Last night I just discovered a DOS point-and-click game named DreamWeb the other night, and downloaded and installed SCUMMVM to play it. So far I love it; it has a well-created atmosphere with solid music and an intentionally dreary cyberpunk aesthetic, the characters have so far been lovably degenerative and original, and the plot is gripping and original with more than a dash of angst.
I don't want to spoil anything, but in essence, the amount I've played of it has been about a man who is plagued by dreams wherein he is told to kill 7 people who will corrupt and destroy the already dark cyber-punk world of the game. The protagonist is rapidly deteriorating mentally and emotionally, becoming resigned to his fate.
There's more than a little uncertainty as to whether the protagonist is actually seeing real events and being affected by real people in these dreams, though; they may just be the internal justifications of a soon-to-be serial killer.
You can find the game here, and elsewhere on the same site you can download a decent engine to run it on modern machines:
http://www.scummvm.org/games